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KMID : 0812020030090010006
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Korean Journal of Neurogastroenterology and Motility
2003 Volume.9 No. 1 p.6 ~ p.11
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The Effect of ltopride, a New Prokinetic, on Acid Reflux Symptoms and Variables in Patients with GERD
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Abstract
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Background/Aims: Itopride is a newly developed prokinetic agent enhancing gastric motility through both antidopaminergic and antiacetylcholinesterase actions. The importance of esophageal motor dysfunction in the pathogenesis of gastro-esophageal reflux disease (GERD) makes it interesting to examine the effect of itopride on esophageal acid exposure. Methods: The effect of itopride on esophageal 24-hour acid reflux variables was studied in 26 patients with GERD symptoms, pre-entry total acid exposure time (pH<4) of more than 5% and mild esophagitis (Savary-Miller grade 1, II) by endoscopy. Ambulatory 24-hour pH monitoring and symptom assessment were performed after treatment with itopride 50 mg or 100 mg t.i.d for 4 weeks by a randomization allocation schedule with an open label. Results: In both itopride groups, total symptom scores were decreased after treatment significantly. Itopride 300 mg was significantly more effective than 150 mg in decreasing the total time and total percent time of intraesophageal pH below 4, and DeMeester score. Consequently, no serious adverse effects were reported after administration in both groups. Conclusions: Itopride 100 mg t.i.d is effective to decrease pathologic reflux in patients with GERD. Therefore, it has a therapeutic potential for this diseases. (The Korean Journal of Gastrointestinal Motility 2003;9:6-11)
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